Definition
A low hemoglobin count is a commonly seen blood test result. Hemoglobin (Hb or Hgb) is a protein in red blood cells that carries oxygen throughout the body.
A low hemoglobin count is generally defined as less than 13.2 grams of hemoglobin per deciliter (132 grams per liter) of blood for men and less than 11.6 grams per deciliter (116 grams per liter) for women. In children, the definition varies with age and sex. These thresholds may differ slightly from one medical practice to another.
In many cases, a low hemoglobin count that’s only slightly lower than normal doesn’t affect how you feel. A low hemoglobin count that’s more severe and causes symptoms might mean you have anemia.
Causes
Normally low hemoglobin counts
A slightly low hemoglobin count isn’t always a sign of illness — it can be normal for some people. Women with menstrual periods and pregnant women commonly have low hemoglobin counts.
Low hemoglobin counts associated with diseases and conditions
A low hemoglobin count can be associated with a disease or condition that causes your body to have too few red blood cells. This can occur if:
Your body produces fewer red blood cells than usual
Your body destroys red blood cells faster than they can be produced
You have blood loss
Diseases and conditions that cause your body to produce fewer red blood cells than normal include:
Aplastic anemia
Cancer
Certain medications, such as antiretroviral drugs for HIV infection and chemotherapy drugs for cancer and other conditions
Chronic kidney disease
Cirrhosis
Hodgkin lymphoma (Hodgkin disease)
Hypothyroidism (underactive thyroid)
Inflammatory bowel disease (IBD)
Iron deficiency anemia
Lead poisoning
Leukemia
Multiple myeloma
Myelodysplastic syndromes
Non-Hodgkin’s lymphoma
Rheumatoid arthritis
Vitamin deficiency anemia
Diseases and conditions that cause your body to destroy red blood cells faster than they can be made include:
Enlarged spleen (splenomegaly)
Hemolysis
Porphyria
Sickle cell anemia
Thalassemia
A low hemoglobin count can also be due to blood loss, which can occur because of:
Bleeding in your digestive tract, such as from ulcers, cancers or hemorrhoids
Frequent blood donation
Heavy menstrual bleeding (heavy menstrual bleeding-although even normal menstrual bleeding may cause a slightly low hemoglobin count)
