Overview
Undifferentiated pleomorphic sarcoma (UPS) is a rare type of cancer that begins mostly in the soft tissues of the body. Soft tissues connect, support and surround other body structures.
UPS usually occurs in the arms or legs. Less often it can happen in the area behind the abdominal organs (retroperitoneum).
The name undifferentiated pleomorphic sarcoma comes from the way the cancer cells appear under the microscope. Undifferentiated means the cells don’t look like the body tissues in which they develop. The cancer is called pleomorphic (plee-o-MOR-fik) because the cells grow in multiple shapes and sizes.
Treatment for UPS depends on the location of the cancer, but often involves surgery, radiation and drug treatments.
UPS used to be called malignant fibrous histiocytoma.
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Symptoms
Undifferentiated pleomorphic sarcoma symptoms depend on where the cancer occurs. It most often happens in the arms and legs, but it can happen anywhere in the body.
Signs and symptoms may include:
- Growing lump or area of swelling.
- If it grows very large, there may be pain, tingling and numbness.
- If it occurs in an arm or leg, there may be swelling in the hand or foot of an affected limb.
- If it occurs in the abdomen, there may be pain, loss of appetite and constipation.
- Fever.
- Weight loss.
When to see a doctor
Make an appointment with a doctor if you develop any persistent signs or symptoms that worry you.
